Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming

Dudeck J, Ghouse SM, Lehmann C, Hoppe A, Schubert N, Nedospasov SA, Dudziak D, Dudeck A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 13

Pages Range: 399-411

Journal Issue: 2

DOI: 10.1016/j.celrep.2015.08.078

Abstract

Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood. Using Mcpt5-CreTNF(FL/FL) mice, we show here that the absence of TNF exclusively in mast cells impaired the expansion of CD8(+) T cells upon sensitization and the T-cell-driven adaptive immune response to elicitation. T cells primed in the absence of mast cell TNF exhibited a diminished efficiency to transfer sensitization to naive recipients. Specifically, mast cell TNF promotes CD8(+) dendritic cell (DC) maturation and migration to draining lymph nodes. The peripherally released mast cell TNF further critically boosts the CD8(+) T-cell-priming efficiency of CD8(+) DCs, thereby linking mast cell effects on T cells to DC modulation. Collectively, our findings identify the distinct potential of mast cell TNF to amplify CD8(+) DC functionality and CD8(+) T-cell-dominated adaptive immunity, which may be of great importance for immunotherapy and vaccination approaches.

Authors with CRIS profile

Christian Lehmann Department of Dermatology Diana Dudziak Professur für die Biologie Dendritischer Zellen

Involved external institutions

Engelhardt Institute of Molecular Biology (EIMB) RU Russian Federation (RU) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Dudeck, J., Ghouse, S.M., Lehmann, C., Hoppe, A., Schubert, N., Nedospasov, S.A.,... Dudeck, A. (2015). Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming. Cell Reports, 13(2), 399-411. https://doi.org/10.1016/j.celrep.2015.08.078

MLA:

Dudeck, Jan, et al. "Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming." Cell Reports 13.2 (2015): 399-411.

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