Brenner S, Drewel D, Steinbart T, Weisel F, Härtel E, Pötzsch S, Welzel H, Brandl A, Yu P, Mudde GC, Schweizer A, Nitschke L, Winkler T (2011)
Publication Status: Published
Publication Type: Journal article
Publication year: 2011
Publisher: NATURE PUBLISHING GROUP
Book Volume: 30
Pages Range: 2705-2718
Journal Issue: 13
The quality and quantity of BCR signals impact on cell fate decisions of B lymphocytes. Here, we describe novel gene-targeted mice, which in the context of normal VDJ recombination show hypomorphic expression of immunoglobulin l heavy chain (mu HC) mRNA levels and hence lower pre-BCR and BCR levels. Hypomorphic expression of mu HC leads to augmented selection processes at all stages of B-cell development, noticeably at the expansion of pre-B cells, the positive selection of immature B lymphocytes in the bone marrow and the selection of the follicular (FO), marginal zone (MZ) and B1 B-lymphocyte compartment in peripheral lymphoid organs. Immature as well as mature FO and MZ B lymphocytes in the peripheral lymphoid organs express lower levels of the receptor for B-cell activating factor (BAFF). In addition, hypomorphic expression of the BCR favours receptor editing. Together, our results highlight the critical importance of pre-BCR and BCR receptor levels for the normal development of B-lymphocyte subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire. The EMBO Journal (2011) 30, 2705-2718. doi:10.1038/emboj.2011.168; Published online 27 May 2011
APA:
Brenner, S., Drewel, D., Steinbart, T., Weisel, F., Härtel, E., Pötzsch, S.,... Winkler, T. (2011). A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO Journal, 30(13), 2705-2718. https://doi.org/10.1038/emboj.2011.168
MLA:
Brenner, Sven, et al. "A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing." EMBO Journal 30.13 (2011): 2705-2718.
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