Wiede F, Fromm PD, Comerford I, Kara E, Bannan J, Schuh W, Ranasinghe C, Tarlinton D, Winkler T, Mccoll SR, Koerner H (2013)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2013
Publisher: NATURE PUBLISHING GROUP
Book Volume: 91
Pages Range: 335-339
Journal Issue: 5
DOI: 10.1038/icb.2013.14
The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naive B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6(-/-) mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6(-/-) B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.
APA:
Wiede, F., Fromm, P.D., Comerford, I., Kara, E., Bannan, J., Schuh, W.,... Koerner, H. (2013). CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse. Immunology and Cell Biology, 91(5), 335-339. https://doi.org/10.1038/icb.2013.14
MLA:
Wiede, Florian, et al. "CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse." Immunology and Cell Biology 91.5 (2013): 335-339.
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