Neurath M, Finotto S (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 29
Pages Range: 93-9
DOI: 10.1016/j.cytogfr.2016.02.002
Recent studies have highlighted a crucial regulatory role of the cytokine IL-9 in driving immune responses in chronic inflammatory and autoimmune diseases at mucosal surfaces. IL-9 activates various types of immune and non-immune cells carrying the membrane bound IL-9R. IL-9 signaling plays a pivotal role in controlling the differentiation and activation of these cells by inducing the Jak/STAT pathway. In particular, IL-9 induces activation of T helper cells and affects the function of various tissue resident cells such as mast cells and epithelial cells in the mucosa. Importantly, recent findings suggest that blockade of IL-9 signaling is effective in treating experimental models of autoimmune and chronic inflammatory diseases such as inflammatory bowel diseases, allergic disorders such as food allergy and asthma. Thus, blockade of IL-9 and IL-9R signaling emerges as potentially novel approach for therapy of inflammatory diseases in the mucosal immune system.
APA:
Neurath, M., & Finotto, S. (2016). IL-9 signaling as key driver of chronic inflammation in mucosal immunity. Cytokine & Growth Factor Reviews, 29, 93-9. https://doi.org/10.1016/j.cytogfr.2016.02.002
MLA:
Neurath, Markus, and Susetta Finotto. "IL-9 signaling as key driver of chronic inflammation in mucosal immunity." Cytokine & Growth Factor Reviews 29 (2016): 93-9.
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