Fatal lymphomatoid granulomatosis with primary CNS-involvement in an immunocompetent 80-year-old woman

Olmes DG, Agaimy A, Kloska S, Linker R (2014)

Publication Type: Journal article

Publication year: 2014

Journal

BMJ Case Reports BMJ Publishing Group

Book Volume: 2014

DOI: 10.1136/bcr-2014-206825

Abstract

An 80-year-old woman presented with weight loss, fatigue, dizziness and a brain stem lesion. Extensive work-up revealed lymphomatoid granulomatosis (LYG) with primary clinical manifestation in the central nervous system (CNS), a rare Epstein-Barr virus-driven multisystem lymphoproliferative disorder, to be causative for the symptoms. Immunochemotherapy consisting of rituximab and temozolomide was started, but the disease progressed and the patient subsequently died. Histology, diagnostic criteria, differential diagnosis and treatment options for LYG with CNS involvement are discussed. This case demonstrates that LYG with CNS involvement may necessitate more aggressive treatment approaches than combination therapy with rituximab and temozolomide.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Stephan Kloska Department of Neuroradiology Ralf Linker Department of Neurology

How to cite

APA:

Olmes, D.G., Agaimy, A., Kloska, S., & Linker, R. (2014). Fatal lymphomatoid granulomatosis with primary CNS-involvement in an immunocompetent 80-year-old woman. BMJ Case Reports, 2014. https://doi.org/10.1136/bcr-2014-206825

MLA:

Olmes, David G., et al. "Fatal lymphomatoid granulomatosis with primary CNS-involvement in an immunocompetent 80-year-old woman." BMJ Case Reports 2014 (2014).

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