Bozec A, Zaiss M (2017)
Publication Type: Journal article
Publication year: 2017
DOI: 10.1007/s11914-017-0356-1
In this review, we present the role of regulatory T (Treg) cells in bone remodelling and bone-related disease such as osteoporosis or inflammatory bone loss. We also discuss the cellular and molecular mechanism how Treg cells regulate osteoclastogenesis.Treg cells could regulate osteoclastogenesis by secreting TGF-? and IL-10 as well as IL-4 cytokines. Moreover, Treg cells can additionally regulate osteoclast differentiation, in a cell-to-cell contact via the cytotoxic T lymphocyte antigen (CTLA-4). The latter induces the apoptosis of osteoclasts dependent on CD80/86 in vitro and in vivo. Treg cells mediate immunosuppressive function that controls undesired immune reactions, such as autoimmunity. Recently, Treg cells have been shown to influence non-immunological processes, such as bone homeostasis. Accumulated evidences have demonstrated that Treg cells can suppress osteoclast differentiation in vitro and in vivo.
APA:
Bozec, A., & Zaiss, M. (2017). T Regulatory Cells in Bone Remodelling. Current Osteoporosis Reports. https://doi.org/10.1007/s11914-017-0356-1
MLA:
Bozec, Aline, and Mario Zaiss. "T Regulatory Cells in Bone Remodelling." Current Osteoporosis Reports (2017).
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