Schrauder MG, Brunel-Geuder L, Häberle L, Wunderle M, Hoyer J, Wiesmann da Silva Reis A, Schulz-Wendtland R, Beckmann M, Lux MP (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 32
Pages Range: 186-191
DOI: 10.1016/j.breast.2017.02.008
Risk-reducing surgeries are a feasible option for mitigating the risk in individuals with inherited susceptibility to cancer, but are the procedures cost-effective in the current health-care system in Germany? This study compared the health-care costs for bilateral risk-reducing mastectomy (BRRM) and risk-reducing (bilateral) salpingo-oophorectomy (RRSO) with cancer treatment costs that could potentially be prevented.The analysis is based on interdisciplinary consultations with individuals with a high familial risk for breast and ovarian cancer at the University Breast Center for Franconia (Germany) between 2009 and 2013 (370 consultations; 44 patients with BRCA1 mutations and 26 with BRCA2 mutations). Health-care costs for risk-reducing surgeries in BRCA mutation carriers were calculated as reimbursements in the German diagnosis-related groups (DRG) hospital pricing system. These costs for the health-care system were compared with the potential cancer treatment costs that could possibly be prevented by risk-reducing surgeries.Long-term health-care costs can be reduced by risk-reducing surgeries after genetic testing in BRCA mutation carriers. The health-care system in Germany would have saved EUR 136,295 if BRRM had been performed and EUR 791,653 if RRSO had been performed before the development of cancer in only 50% of the 70 mutation carriers seen in our center. Moreover, in patients with combined RRSO and BRRM (without breast reconstruction), one further life-year for a 40-year-old BRCA mutation carrier would cost EUR 2,183.Intensive care, including risk-reducing surgeries in BRCA mutation carriers, is cost-effective from the point of view of the health-care system in Germany.
APA:
Schrauder, M.G., Brunel-Geuder, L., Häberle, L., Wunderle, M., Hoyer, J., Wiesmann da Silva Reis, A.,... Lux, M.P. (2017). Cost-effectiveness of risk-reducing surgeries in preventing hereditary breast and ovarian cancer. BREAST , 32, 186-191. https://doi.org/10.1016/j.breast.2017.02.008
MLA:
Schrauder, Michael G., et al. "Cost-effectiveness of risk-reducing surgeries in preventing hereditary breast and ovarian cancer." BREAST 32 (2017): 186-191.
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