Lanig H, Othersen O, Seidel U, Beierlein F, Exner T, Clark T (2006)
Publication Status: Published
Publication Type: Journal article
Publication year: 2006
Publisher: American Chemical Society
Book Volume: 49
Pages Range: 3444-3447
Journal Issue: 12
DOI: 10.1021/jm060289g
The binding motif ( pharmacophore) for induction and the changes in the structure of the binding site that accompany induction have been determined from molecular-dynamics simulations on the tetracycline-repressor signal-transduction protein. The changes and the induction mechanism are discussed and compared with conclusions drawn from earlier X-ray structures. The differences in inducer strength of tetracycline and 5a, 6-anhydrotetracycline are discussed with respect to their interaction in the MD simulations.
APA:
Lanig, H., Othersen, O., Seidel, U., Beierlein, F., Exner, T., & Clark, T. (2006). Structural changes and binding characteristics of the tetracycline-repressor binding site on induction. Journal of Medicinal Chemistry, 49(12), 3444-3447. https://doi.org/10.1021/jm060289g
MLA:
Lanig, Harald, et al. "Structural changes and binding characteristics of the tetracycline-repressor binding site on induction." Journal of Medicinal Chemistry 49.12 (2006): 3444-3447.
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