Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer

Daniel C, Gerlach K, Vaeth M, Neurath M, Weigmann B (2014)

Publication Type: Journal article

Publication year: 2014

Journal

International Journal of Cancer Wiley-Blackwell

Book Volume: 134

Pages Range: 1767-75

Journal Issue: 8

DOI: 10.1002/ijc.28329

Abstract

Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.

Authors with CRIS profile

Katharina Gerlach Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Neurath Lehrstuhl für Innere Medizin I Benno Weigmann Medizinische Fakultät

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Daniel, C., Gerlach, K., Vaeth, M., Neurath, M., & Weigmann, B. (2014). Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer. International Journal of Cancer, 134(8), 1767-75. https://doi.org/10.1002/ijc.28329

MLA:

Daniel, Carolin, et al. "Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer." International Journal of Cancer 134.8 (2014): 1767-75.

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