Engelhorn T, Schwarz M, Heß A, Budinsky L, Pitann P, Eyüpoglu IY, Dörfler A (2014)
Publication Type: Journal article
Publication year: 2014
Publisher: Springer Verlag (Germany)
Book Volume: 24
Pages Range: 337-45
Journal Issue: 4
DOI: 10.1007/s00062-013-0257-3
To define K(trans) and fractional anisotropy (FA) thresholds in correlation to histology for improved magnetic resonance imaging (MRI) tumor assessment in an animal model of brain glioma.Twelve rats underwent 4.7 T MRI at day 10 after tumor implantation. Anatomical scans (T2, T1 at 8 min after double dose contrast application) as well as dynamic contrast-enhanced (DCE) imaging with calculation of K(trans) and diffusion tensor imaging (DTI) with calculation of FA were performed. T2- and T1-derived tumor volumes were calculated and thresholds for K(trans) and FA were defined for best MRI tumor assessment correlated to histology.Tumor volumes were 159 ± 14 mm(3) (histology), 126 ± 26 mm(3) (T1 with contrast, r = 0.76), and 153 ± 12 mm(3) (T2, r = 0.84), respectively. K(trans)- and FA-derived tumor volumes were 160 ± 16 mm(3) (for K(trans) ³ 0.04 min(-1), r = 0.94), and 159 ± 14 mm(3) (for FA £ 0.14, r = 0.96), respectively.DCE-MRI and DTI with calculation of K(trans) and FA maps allow very precise brain glioma assessment comparable to histology if established thresholds for the given tumor model are used.
APA:
Engelhorn, T., Schwarz, M., Heß, A., Budinsky, L., Pitann, P., Eyüpoglu, I.Y., & Dörfler, A. (2014). Definition of K(trans) and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study. Clinical Neuroradiology, 24(4), 337-45. https://doi.org/10.1007/s00062-013-0257-3
MLA:
Engelhorn, Tobias, et al. "Definition of K(trans) and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study." Clinical Neuroradiology 24.4 (2014): 337-45.
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