Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity

Bauer R, Valletta D, Bauer K, Thasler WE, Hartmann A, Mueller M, Reichert TE, Hellerbrand C (2014)

Publication Type: Journal article

Publication year: 2014

Journal

International Journal of Clinical and Experimental Pathology e-Century Publishing

Book Volume: 7

Pages Range: 6125-32

Journal Issue: 9

Abstract

P-cadherin is a major contributor to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes and in maintaining tissue integrity and homeostasis. Alterations of P-cadherin expression have been observed during the progression of several carcinomas where it appears to act as tumor suppressive or oncogenic in a context-dependent manner. Here, we found a significant downregulation of P-cadherin in hepatocellular carcinoma (HCC) cell lines and tissues compared to primary human hepatocytes and non-malignant liver tissues. Combined immunohistochemical analysis of a tissue microarray containing matched pairs of HCC tissue and corresponding non-tumorous liver tissue of 69 patients confirmed reduced P-cadherin expression in more than half of the cases. In 35 human HCC tissues, the P-cadherin immunosignal was completely lost which correlated with tumor staging and proliferation. Also in vitro, P-cadherin suppression in HCC cells via siRNA induced proliferation compared to cells transfected with control-siRNA. In summary, downregulation of P-cadherin expression appears to induce tumorigenicity in HCC. Therefore, P-cadherin expression may serve as a prognostic marker and therapeutic target of this highly aggressive tumor.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universitätsklinikum Regensburg DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE)

How to cite

APA:

Bauer, R., Valletta, D., Bauer, K., Thasler, W.E., Hartmann, A., Mueller, M.,... Hellerbrand, C. (2014). Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity. International Journal of Clinical and Experimental Pathology, 7(9), 6125-32.

MLA:

Bauer, Richard, et al. "Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity." International Journal of Clinical and Experimental Pathology 7.9 (2014): 6125-32.

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