Schneider A, Schneider MP, Krieter DH, Genser B, Scharnagl H, Stojakovic T, Wanner C, Drechsler C (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 10
Pages Range: e0128079
Journal Issue: 5
DOI: 10.1371/journal.pone.0128079
In patients undergoing maintenance hemodialysis (HD), increased levels of circulating fibroblast growth factor-23 (FGF-23) are independently associated with cardiovascular events and mortality. Interventional strategies aiming to reduce levels of FGF-23 in HD patients are of particular interest. The purpose of the current study was to compare the impact of high-flux versus low-flux HD on circulating FGF-23 levels.We conducted a post-hoc analysis of the MINOXIS study, including 127 dialysis patients randomized to low-flux (n = 62) and high-flux (n = 65) HD for 52 weeks. Patients with valid measures for FGF-23 investigated baseline and after 52 weeks were included.Compared to baseline, a significant increase in FGF-23 levels after one year of low-flux HD was observed (Delta plasma FGF-23: +4026 RU/ml; p < 0.001). In contrast, FGF-23 levels remained stable in the high flux group (Delta plasma FGF-23: +373 RU/ml, p = 0.70). The adjusted difference of the absolute change in FGF-23 levels between the two treatment groups was statistically significant (p < 0.01).Over a period of 12 months, high-flux HD was associated with stable FGF-23 levels, whereas the low-flux HD group showed an increase of FGF-23. However, the implications of the different FGF 23 time-trends in patients on high flux dialysis, as compared to the control group, remain to be explored in specifically designed clinical trials.German Clinical Trials Register (DRKS) DRKS00007612.
APA:
Schneider, A., Schneider, M.P., Krieter, D.H., Genser, B., Scharnagl, H., Stojakovic, T.,... Drechsler, C. (2015). Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial. PLoS ONE, 10(5), e0128079. https://dx.doi.org/10.1371/journal.pone.0128079
MLA:
Schneider, Andreas, et al. "Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial." PLoS ONE 10.5 (2015): e0128079.
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