Immunotherapy of uveal melanoma: vaccination against cancer : Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma

Schuler-Thurner B, Bartz-Schmidt KU, Bornfeld N, Cursiefen C, Fuisting B, Grisanti S, Heindl LM, Holbach L, Keserue M, Knorr H, Koch K, Kruse F, Meiller R, Metz C, Meyer-Ter-Vehn T, Much M, Reinsberg M, Schliep S, Seitz B, Schuler G, Suesskind D, Viestenz A, Wagenfeld L, Zeschnigk M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Ophthalmologe Springer Verlag (Germany)

Book Volume: 112

Pages Range: 1017-21

Journal Issue: 12

DOI: 10.1007/s00347-015-0162-z

Abstract

Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene expression analysis, these tumors can be categorized into highly aggressive (monosomy 3, class II) and less aggressive forms. This molecular biological stratification is primarily important for determining the risk of these tumors as no therapy is currently available that is able to prevent or delay metastases. A randomized study of patients with a poor prognosis (monosomy 3) is currently being carried out in order to determine whether a cancer vaccine prepared from autologous (patient's own) dendritic cells and uveal melanoma RNA can prevent or delay progression and further metastases of this extremely aggressive form of cancer. Inclusion in the uveal melanoma study, which hopes to provide a potential therapeutic option for patients, is only possible if patients are referred to an institution that is able to manufacture and provide this vaccination before the patient is operated on or treated with radiation. Untreated tumor material is necessary for producing the vaccine on an individualized patient basis.

Authors with CRIS profile

Beatrice Schuler-Thurner Lehrstuhl für Haut- und Geschlechtskrankheiten Friedrich Kruse Lehrstuhl für Augenheilkunde Gerold Schuler Lehrstuhl für Haut- und Geschlechtskrankheiten

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE) Universitätsklinikum Essen DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Schuler-Thurner, B., Bartz-Schmidt, K.-U., Bornfeld, N., Cursiefen, C., Fuisting, B., Grisanti, S.,... Zeschnigk, M. (2015). Immunotherapy of uveal melanoma: vaccination against cancer : Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma. Ophthalmologe, 112(12), 1017-21. https://doi.org/10.1007/s00347-015-0162-z

MLA:

Schuler-Thurner, Beatrice, et al. "Immunotherapy of uveal melanoma: vaccination against cancer : Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma." Ophthalmologe 112.12 (2015): 1017-21.

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