Improvement of albuminuria after renal denervation

Ott C, Mahfoud F, Schmid A, Ditting T, Veelken R, Ewen S, Ukena C, Uder M, Boehm M, Schmieder R (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 173

Pages Range: 311-5

Journal Issue: 2

DOI: 10.1016/j.ijcard.2014.03.017

Abstract

The primary objective of this study was the effect of renal denervation (RDN) on elevated urinary albumin-to-creatinine ratio (UACR) in treatment-resistant hypertensive patients. In addition, patients were stratified according their UACR at baseline into micro- (30-300 mg/g, n=37) and macroalbuminuria (>= 300 mg/g, <2,200 mg/g, n=22).Increased albuminuria indicates cardiovascular and renal damage in hypertension. RDN emerged as an innovative interventional approach to reduce blood pressure (BP) and may thus reduce albumin urinary excretion.Fifty-nine treatment-resistant hypertensive patients with elevated UACR at baseline underwent catheter-based RDN using the Symplicity Flex(TM) catheter (Medtronic Inc., Santa Rosa, CA).In the whole and pre-specified subgroups both office and 24-h ambulatory BP were significantly reduced 6 months after RDN. In parallel, a significant reduction in UACR occurred in all patients (160 (65-496) versus 89 (29-319) mg/g creatinine, p<0.001) and in both subgroups (microalbuminuria: 83 (49-153) versus 58 (17-113) mg/g creatinine, p=0.001; macroalbuminuria: (536 (434-1483) versus 478 (109-1080) mg/g creatinine, p<0.001). In accordance, the prevalence of micro- and macroalbuminuria decreased significantly. Regression analysis revealed a modest positive relationship between the decrease of UACR and the fall of systolic BP (?=0.340, p=0.039) independent of renal function. Renal function remained unchanged after RDN.In summary, following RDN, the magnitude of albuminuria as well as the prevalence of micro- and macroalbuminuria decreased in treatment-resistant hypertensive patients. Since albuminuria is an independent renal and cardiovascular risk factor, our findings suggest a reduction of renal and cardiovascular risk in these patients.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) Germany (DE)

How to cite

APA:

Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Veelken, R., Ewen, S.,... Schmieder, R. (2014). Improvement of albuminuria after renal denervation. International Journal of Cardiology, 173(2), 311-5. https://doi.org/10.1016/j.ijcard.2014.03.017

MLA:

Ott, Christian, et al. "Improvement of albuminuria after renal denervation." International Journal of Cardiology 173.2 (2014): 311-5.

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