Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals

Tziridis K, Ahlf S, Jeschke M, Happel MFK, Ohl FW, Schulze H (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Frontiers in Neurology Frontiers Research Foundation / Frontiers Media

Book Volume: 6

Pages Range: 22

DOI: 10.3389/fneur.2015.00022

Abstract

In this study, we describe differences between neural plasticity in auditory cortex (AC) of animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) compared to those that did not [group non-tinnitus (NT)]. To this end, our analysis focuses on the input activity of cortical neurons based on the temporal and spectral analysis of local field potential (LFP) recordings and an in-depth analysis of auditory brainstem responses (ABR) in the same animals. In response to NIHL in NT animals we find a significant general reduction in overall cortical activity and spectral power as well as changes in all ABR wave amplitudes as a function of loudness. In contrast, T-animals show no significant change in overall cortical activity as assessed by root mean square analysis of LFP amplitudes, but a specific increase in LFP spectral power and in the amplitude of ABR wave V reflecting activity in the inferior colliculus (IC). Based on these results, we put forward a refined model of tinnitus prevention after NIHL that acts via a top-down global (i.e., frequency-unspecific) inhibition reducing overall neuronal activity in AC and IC, thereby counteracting NIHL-induced bottom-up frequency-specific neuroplasticity suggested in current models of tinnitus development.

Authors with CRIS profile

Konstantin Tziridis Department of Otorhinolaryngology – Head and Neck Surgery Sönke Ahlf Professur für Experimentelle HNO-Heilkunde Holger Schulze Professur für Experimentelle HNO-Heilkunde

Involved external institutions

Max-Planck-Institut für Neurobiologie / Max Planck Institute of Neurobiology DE Germany (DE)

How to cite

APA:

Tziridis, K., Ahlf, S., Jeschke, M., Happel, M.F.K., Ohl, F.W., & Schulze, H. (2015). Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals. Frontiers in Neurology, 6, 22. https://doi.org/10.3389/fneur.2015.00022

MLA:

Tziridis, Konstantin, et al. "Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals." Frontiers in Neurology 6 (2015): 22.

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