Rath T, Billmeier U, Waldner M, Atreya R, Neurath M (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 89
Pages Range: 541-54
Journal Issue: 4
DOI: 10.1007/s00204-015-1461-5
Since its discovery in 1986, originally as B cell stimulating factor 2, the knowledge on IL-6 for immune homeostasis and its pathophysiological implications has rapidly increased. It is now clear that IL-6, alone or in combination with other cytokines, is an architect for shaping and generating immune responses which exerts profound activities on the induction of acute-phase reactions, the differentiation of B lymphocytes, the modulation of T cell apoptosis, the activation of T helper cells and the balance between regulatory T cells and Th17 cells. In parallel to the identification of these physiologic functions, IL-6 has emerged as a critical mediator for perpetuating chronic inflammation and autoimmunity and is increasingly recognized as a key cytokine for linking chronic inflammation to cancer development. In this review, we begin by briefly summarizing the molecular events of IL-6 regulation and signaling and then describe the role of IL-6 in orchestrating innate and adaptive immune responses and its immunopathological relevance for chronic inflammatory diseases. We further outline how IL-6 links chronic inflammation and cancer development and finally provide an outlook on novel therapeutic strategies targeting IL-6 signaling for the treatment of chronic inflammatory diseases and cancer.
APA:
Rath, T., Billmeier, U., Waldner, M., Atreya, R., & Neurath, M. (2015). From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Archives of Toxicology, 89(4), 541-54. https://doi.org/10.1007/s00204-015-1461-5
MLA:
Rath, Timo, et al. "From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis." Archives of Toxicology 89.4 (2015): 541-54.
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