Geographical sequence variation in the Leishmania major virulence factor P46

Bifeld E, Chrobak M, Zander D, Schleicher U, Schoenian G, Clos J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Infection Genetics and Evolution Elsevier

Book Volume: 30

Pages Range: 195-205

DOI: 10.1016/j.meegid.2014.12.029

Abstract

Cutaneous leishmaniasis as caused by Leishmania major is a zoonotic infection with wide epidemiological impact. The L. major P46 virulence gene was shown to boost the parasite's virulence and extends its range of experimental hosts. Here we show that P46 is subject to significant geographical sequence variations that may reflect the adaption to different reservoir hosts. This view is supported by the results of passage experiments using P46 variants in different experimental hosts. Conversely, loss of P46 expression leads to attenuation both in vitro and in BALB/c mice. Although part of the L. major exosomal protein payload, P46 is not required for exosome-mediated immune modulation.

Involved external institutions

Bernhard-Nocht-Institut für Tropenmedizin (BNITM) / Bernhard Nocht Institute for Tropical Medicine DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Bifeld, E., Chrobak, M., Zander, D., Schleicher, U., Schoenian, G., & Clos, J. (2015). Geographical sequence variation in the Leishmania major virulence factor P46. Infection Genetics and Evolution, 30, 195-205. https://dx.doi.org/10.1016/j.meegid.2014.12.029

MLA:

Bifeld, Eugenia, et al. "Geographical sequence variation in the Leishmania major virulence factor P46." Infection Genetics and Evolution 30 (2015): 195-205.

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