The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions

Schmitz U, Naderi-Meshkin H, Gupta SK, Wolkenhauer O, Vera J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Briefings in Bioinformatics Oxford University Press

Book Volume: 17

Pages Range: 380-92

Journal Issue: 3

DOI: 10.1093/bib/bbv061

Abstract

There was evidence that RNAs are a functionally rich class of molecules not only since the arrival of the next-generation sequencing technology. Non-coding RNAs (ncRNA) could be the key to accelerated diagnosis and enhanced prediction of disease and therapy outcomes as well as the design of advanced therapeutic strategies to overcome yet unsatisfactory approaches.In this review, we discuss the state of the art in RNA systems biology with focus on the application in the systems biomedicine field. We propose guidelines for analysing the role of microRNAs and long non-coding RNAs in human pathologies. We introduce RNA expression profiling and network approaches for the identification of stable and effective RNomics-based biomarkers, providing insights into the role of ncRNAs in disease regulation. Towards this, we discuss ways to model the dynamics of gene regulatory networks and signalling pathways that involve ncRNAs. We also describe data resources and computational methods for finding putative mechanisms of action of ncRNAs. Finally, we discuss avenues for the computer-aided design of novel RNA-based therapeutics.

Authors with CRIS profile

Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

Universität Rostock DE Germany (DE) ACECR Academic Center for Education, Culture and Research IR Iran, Islamic Republic of (IR) University of Sydney (USYD) AU Australia (AU)

How to cite

APA:

Schmitz, U., Naderi-Meshkin, H., Gupta, S.K., Wolkenhauer, O., & Vera, J. (2016). The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions. Briefings in Bioinformatics, 17(3), 380-92. https://doi.org/10.1093/bib/bbv061

MLA:

Schmitz, Ulf, et al. "The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions." Briefings in Bioinformatics 17.3 (2016): 380-92.

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