Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve
Lang H, Xing Y, Brown LN, Samuvel DJ, Panganiban CH, Havens LT, Balasubramanian S, Wegner M, Krug EL, Barth JL (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 5
Pages Range: 13383
DOI: 10.1038/srep13383
Abstract
The auditory nerve is the primary conveyor of hearing information from sensory hair cells to the brain. It has been believed that loss of the auditory nerve is irreversible in the adult mammalian ear, resulting in sensorineural hearing loss. We examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy. Following neuronal degeneration, quiescent glial cells converted to an activated state showing a decrease in nuclear chromatin condensation, altered histone deacetylase expression and up-regulation of numerous genes associated with neurogenesis or development. Neurosphere formation assays showed that adult auditory nerves contain neural stem/progenitor cells (NSPs) that were within a Sox2-positive glial population. Production of neurospheres from auditory nerve cells was stimulated by acute neuronal injury and hypoxic conditioning. These results demonstrate that a subset of glial cells in the adult auditory nerve exhibit several characteristics of NSPs and are therefore potential targets for promoting auditory nerve regeneration.
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APA:
Lang, H., Xing, Y., Brown, L.N., Samuvel, D.J., Panganiban, C.H., Havens, L.T.,... Barth, J.L. (2015). Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve. Scientific Reports, 5, 13383. https://doi.org/10.1038/srep13383
MLA:
Lang, Hainan, et al. "Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve." Scientific Reports 5 (2015): 13383.
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