Donor-related risk factors and preoperative recipient-related risk factors for graft failure
Yu AL, Kaiser M, Schaumberger M, Messmer E, Kook D, Welge-Lüssen UC (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 33
Pages Range: 1149-56
Journal Issue: 11
DOI: 10.1097/ICO.0000000000000225
Abstract
The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure.In this study, 377 medical records of patients, who underwent penetrating keratoplasty between 2001 and 2011, were reviewed. Organ-cultured donor corneas were obtained from the eye bank, Ludwig-Maximilians-University, Munich, Germany. Donor-related and preoperative recipient-related risk factors for graft failure were analyzed by univariate and multivariate analyses.Graft failure occurred in 26% of patients. The following preoperative factors were significantly associated with graft failure by multivariate analyses: high donor age, low donor endothelial cell density, high patient age, indications of infectious keratitis, acute perforation of noninfectious keratitis, prior graft failure, chemical burn, trauma, glaucoma-associated corneal decompensation, high-risk graft indications, corneal edema, anterior chamber lens, diabetes mellitus, atopy, and autoimmune diseases.This study demonstrated a success rate of 74%, which is consistent with previous studies. Various preoperative recipient-related factors seem to influence the outcome of penetrating keratoplasties, whereas few donor-related factors have a significant association with graft failure.
Involved external institutions
Germany (DE)How to cite
APA:
Yu, A.L., Kaiser, M., Schaumberger, M., Messmer, E., Kook, D., & Welge-Lüssen, U.-C. (2014). Donor-related risk factors and preoperative recipient-related risk factors for graft failure. Cornea, 33(11), 1149-56. https://dx.doi.org/10.1097/ICO.0000000000000225
MLA:
Yu, Alice L., et al. "Donor-related risk factors and preoperative recipient-related risk factors for graft failure." Cornea 33.11 (2014): 1149-56.
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