Nebel N, Maschauer S, Bartuschat A, Fehler S, Hübner H, Gmeiner P, Kuwert T, Heinrich M, Prante O, Hocke C (2014)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2014
Publisher: Elsevier
Book Volume: 24
Pages Range: 5399-5403
DOI: 10.1016/j.bmcl.2014.10.043
A series of fluoro substituted pyridinylcarboxamides and their phenylazo analogues with high affinity and selectivity for the dopamine D3 receptor was synthesized by the use of 6-fluoropyridine-3-carbonyl chloride (1) and fluorophenylazocarboxylic ester (2). Several of these compounds (9a-e and 10a-h) have been evaluated in vitro, among which 9b, 10a, 10c and 10d proved to have at least single-digit nanomolar affinity for D3. They also exhibit considerable selectivity over the other dopamine receptor subtypes and noteworthy selectivity over the structurally related serotonin receptor subtypes 5-HT
APA:
Nebel, N., Maschauer, S., Bartuschat, A., Fehler, S., Hübner, H., Gmeiner, P.,... Hocke, C. (2014). Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging. Bioorganic & Medicinal Chemistry Letters, 24, 5399-5403. https://doi.org/10.1016/j.bmcl.2014.10.043
MLA:
Nebel, Natascha, et al. "Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging." Bioorganic & Medicinal Chemistry Letters 24 (2014): 5399-5403.
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