Skin sodium measured with ²³Na MRI at 7.0 T

Linz P, Santoro D, Renz W, Rieger J, Ruehle A, Ruff J, Deimling M, Rakova N, Muller DN, Luft FC, Titze J, Niendorf T (2015)

Publication Type: Journal article

Publication year: 2015

Journal

NMR in Biomedicine Wiley

Book Volume: 28

Pages Range: 54-62

Journal Issue: 1

DOI: 10.1002/nbm.3224

Abstract

Skin sodium (Na(+) ) storage, as a physiologically important regulatory mechanism for blood pressure, volume regulation and, indeed, survival, has recently been rediscovered. This has prompted the development of MRI methods to assess Na(+) storage in humans ((23) Na MRI) at 3.0 T. This work examines the feasibility of high in-plane spatial resolution (23) Na MRI in skin at 7.0 T. A two-channel transceiver radiofrequency (RF) coil array tailored for skin MRI at 7.0 T (f = 78.5 MHz) is proposed. Specific absorption rate (SAR) simulations and a thorough assessment of RF power deposition were performed to meet the safety requirements. Human skin was examined in an in vivo feasibility study using two-dimensional gradient echo imaging. Normal male adult volunteers (n = 17; mean ± standard deviation, 46 ± 18 years; range, 20-79 years) were investigated. Transverse slices of the calf were imaged with (23) Na MRI using a high in-plane resolution of 0.9 × 0.9 mm(2) . Skin Na(+) content was determined using external agarose standards covering a physiological range of Na(+) concentrations. To assess the intra-subject reproducibility, each volunteer was examined three to five times with each session including a 5-min walk and repositioning/preparation of the subject. The age dependence of skin Na(+) content was investigated. The (23) Na RF coil provides improved sensitivity within a range of 1 cm from its surface versus a volume RF coil which facilitates high in-plane spatial resolution imaging of human skin. Intra-subject variability of human skin Na(+) content in the volunteer population was <10.3%. An age-dependent increase in skin Na(+) content was observed (r = 0.78). The assignment of Na(+) stores with (23) Na MRI techniques could be improved at 7.0 T compared with current 3.0 T technology. The benefits of such improvements may have the potential to aid basic research and clinical applications designed to unlock questions regarding the Na(+) balance and Na(+) storage function of skin.

Authors with CRIS profile

Peter Linz Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien Jens Titze Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Siemens AG, Healthcare Sector DE Germany (DE) Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch DE Germany (DE) Experimental and Clinical Research Center (ECRC) DE Germany (DE)

How to cite

APA:

Linz, P., Santoro, D., Renz, W., Rieger, J., Ruehle, A., Ruff, J.,... Niendorf, T. (2015). Skin sodium measured with ²³Na MRI at 7.0 T. NMR in Biomedicine, 28(1), 54-62. https://doi.org/10.1002/nbm.3224

MLA:

Linz, Peter, et al. "Skin sodium measured with ²³Na MRI at 7.0 T." NMR in Biomedicine 28.1 (2015): 54-62.

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