Outcome analysis of liver stiffness by ARFI (acoustic radiation force impulse) elastometry in patients with chronic viral hepatitis B and C

Görtz R, Sturm J, Zopf S, Wildner D, Neurath M, Strobel D (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Clinical Radiology WB Saunders

Book Volume: 69

Pages Range: 275-9

Journal Issue: 3

DOI: 10.1016/j.crad.2013.10.011

Abstract

To evaluate the association between liver stiffness measured by acoustic radiation force impulse (ARFI) elastometry and the outcome of antiviral treatment in patients with chronic viral hepatitis B and C.Thirty-eight patients with chronic viral hepatitis B (n = 16) or hepatitis C (n = 22) underwent liver biopsy and ARFI elastometry of the right hepatic lobe. A follow-up assessment using ARFI was performed a mean of 2.3 years after the baseline evaluation. The patients with favourable outcome were classified in group S and those receiving no treatment, showing no response to treatment, or experiencing a relapse were classified in group N.The 38 patients had an initial mean ARFI value of 1.56 ± 0.62 m/s as compared with 1.54 ± 0.64 m/s in the follow-up evaluation. Group S showed a significant decline in ARFI values (1.55 ± 0.60 m/s versus 1.34 ± 0.47 m/s; p < 0.05) and included 16 (64%) patients with lower shear wave velocities at follow-up. In group N, liver stiffness values showed a slight but not significant increase (1.57 ± 0.70 m/s versus 1.93 ± 0.77 m/s).Changes in liver stiffness during antiviral therapy can be assessed by ARFI reflecting response or no response. ARFI elastometry is an additional, useful tool for the follow-up assessment of treatment outcome in patients with chronic viral hepatitis B or C infection.

Authors with CRIS profile

Rüdiger Görtz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Jörg Sturm Medizinische Fakultät Steffen Zopf Medizinische Fakultät Markus Neurath Lehrstuhl für Innere Medizin I Deike Strobel Medizinische Fakultät

How to cite

APA:

Görtz, R., Sturm, J., Zopf, S., Wildner, D., Neurath, M., & Strobel, D. (2014). Outcome analysis of liver stiffness by ARFI (acoustic radiation force impulse) elastometry in patients with chronic viral hepatitis B and C. Clinical Radiology, 69(3), 275-9. https://doi.org/10.1016/j.crad.2013.10.011

MLA:

Görtz, Rüdiger, et al. "Outcome analysis of liver stiffness by ARFI (acoustic radiation force impulse) elastometry in patients with chronic viral hepatitis B and C." Clinical Radiology 69.3 (2014): 275-9.

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