Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI
Crema MD, Roemer F, Li L, Alexander RC, Chessell IP, Dudley AD, Karlsten R, Rosen LB, Guermazi A (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 25
Pages Range: 267-271
Journal Issue: 2
DOI: 10.1016/j.joca.2016.09.016
Abstract
To compare different semiquantitative and quantitative methods using both non-enhanced and gadolinium-enhanced MRI techniques for the assessment of synovitis in knee osteoarthritis (OA).Knees with end-stage clinical OA in patients undergoing total knee replacement surgery were included in this cross-sectional study. MRI was performed on all knees. Standard non-enhanced and gadolinium-enhanced sequences were acquired. Using non-enhanced MRI, we semiquantitatively assessed two features widely used as surrogates for synovitis: effusion-synovitis and Hoffa-synovitis. Using gadolinium-enhanced sequences, we semiquantitatively assessed synovial thickness. We quantitatively evaluated the total synovial volume on the gadolinium-enhanced sequences as well. We assessed the correlations of effusion-synovitis and Hoffa-synovitis with synovial thickness and volume, applying Spearman correlation analysis. The diagnostic performance of both synovitis features on non-enhanced MRI was assessed using synovial thickness on gadolinium-enhanced MRI as the reference.A total of 104 subjects (one knee per subject) were included. Correlations of effusion-synovitis with synovial thickness and volume were r = 0.41 and r = 0.43 (P < .001) r = 0.32 and r = 0.39 (P < .0001).Using synovial thickness assessed on gadolinium-enhanced sequences as the reference, effusion-synovitis showed superior correlations and sensitivity. Effusion-synovitis should be preferred over Hoffa-synovitis as a surrogate marker for synovial thickening, in studies of knee OA for which gadolinium-enhanced sequences are not available.
Authors with CRIS profile
Involved external institutions
Boston University
United States (USA) (US)
Flex Pharma
United States (USA) (US)
Uppsala University
Sweden (SE)
Pfizer, Inc.
United States (USA) (US)
Harvard University
United States (USA) (US)
United States (USA) (US)
Flex Pharma
United States (USA) (US)
Uppsala University
Sweden (SE)
Pfizer, Inc.
United States (USA) (US)
Harvard University
United States (USA) (US)
How to cite
APA:
Crema, M.D., Roemer, F., Li, L., Alexander, R.C., Chessell, I.P., Dudley, A.D.,... Guermazi, A. (2017). Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI. Osteoarthritis and Cartilage, 25(2), 267-271. https://doi.org/10.1016/j.joca.2016.09.016
MLA:
Crema, M. D., et al. "Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI." Osteoarthritis and Cartilage 25.2 (2017): 267-271.
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