Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

Schwartz C, Turqueti-Neves A, Hartmann S, Yu P, Nimmerjahn F, Vöhringer D (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences

Publisher: National Academy of Sciences

Book Volume: 111

Pages Range: E5169-77

Journal Issue: 48

DOI: 10.1073/pnas.1412663111

Abstract

Basophils orchestrate protection against reinfections with gastrointestinal helminths and ticks, but the underlying mechanisms remain elusive. We investigated the role of Fc receptors on basophils, the antibody isotypes IgG1 and IgE, and basophil-derived IL-4/IL-13 during challenge infections with Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Using mixed bone marrow chimeras, we found that activating Fc receptors on basophils were required for protective immunity but not for regulation of basophil homeostasis. Furthermore, rapid worm expulsion was impaired in IgE-deficient but not in IgG1-deficient mice. Basophils promoted the recruitment of other effector cells into the small intestine and induced expression of the antihelminthic proteins resistin-like molecule ? and mucin 5ac. Selective deletion of IL-4/IL-13 in basophils resulted in impaired worm expulsion. Collectively, our results indicate that IgE-mediated activation of basophils and the release of basophil-derived IL-4/IL-13 are critical steps in protective immunity against helminths. Therefore, development of effective vaccines against helminths should consider boosting the IL-4/IgE/basophil axis of the immune system.

Authors with CRIS profile

Christian Schwartz Department of Infection Biology Falk Nimmerjahn Lehrstuhl für Genetik David Vöhringer Department of Infection Biology

Involved external institutions

Freie Universität Berlin DE Germany (DE) Philipps-Universität Marburg DE Germany (DE)

How to cite

APA:

Schwartz, C., Turqueti-Neves, A., Hartmann, S., Yu, P., Nimmerjahn, F., & Vöhringer, D. (2014). Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proceedings of the National Academy of Sciences of the United States of America, 111(48), E5169-77. https://doi.org/10.1073/pnas.1412663111

MLA:

Schwartz, Christian, et al. "Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion." Proceedings of the National Academy of Sciences of the United States of America 111.48 (2014): E5169-77.

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