Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception
Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krueger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Pages Range: 15922
DOI: 10.1038/ncomms15922
Abstract
Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception.
Authors with CRIS profile
Involved external institutions
Johannes Gutenberg-Universität Mainz (JGU)
Germany (DE)
Swiss Integrative Center for Human Health
Switzerland (CH)
Universität zu Köln
Germany (DE)
Spanish National Center for Cardiovascular Research / Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Spain (ES)
Goethe-Universität Frankfurt am Main
Germany (DE)
Germany (DE)
Swiss Integrative Center for Human Health
Switzerland (CH)
Universität zu Köln
Germany (DE)
Spanish National Center for Cardiovascular Research / Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Spain (ES)
Goethe-Universität Frankfurt am Main
Germany (DE)
How to cite
APA:
Bicker, F., Vasic, V., Horta, G., Ortega, F., Nolte, H., Kavyanifar, A.,... Schmidt, M.H.H. (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nature Communications, 8, 15922. https://doi.org/10.1038/ncomms15922
MLA:
Bicker, Frank, et al. "Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception." Nature Communications 8 (2017): 15922.
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