Melatonin analogue agomelatine reduces rabbit's intraocular pressure in normotensive and hypertensive conditions
Martinez-Aguila A, Fonseca B, Bergua A, Pintor J (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 701
Pages Range: 213-7
Journal Issue: 1-3
DOI: 10.1016/j.ejphar.2012.12.009
Abstract
In the search for new compounds to reduce intraocular pressure (IOP), with fewer side effects, we have found that agomelatine, a melatonin analogue, can reduce IOP being, therefore, interesting for the treatment of ocular hypertension and glaucoma. In normotensive conditions, agomelatine (10?l 100?M) reduced IOP by 20.8±1.4% (n=18) with a maximal effect 180min after the compound application and 68.8±5.7% (n=8) in a hypertensive condition. Concentration-response curve depicted a sigmoid behaviour presenting a pD2 value of 9.7±0.3 which was equivalent to an EC50 of 0.19nM. The effect of agomelatine was partially antagonized by 4PPDOT (MT2 antagonist receptor. 10?l 100?M) and prazosin (MT3 antagonist receptor. 10?l 100?M) (85.6±1.6% and 87.2±1.9%, N=18 respectively.) Agomelatine hypotensive effect in normotensive condition was comparable to latanoprost (40?l) and brimonidine (40?l) and it was no so effective as dorzolamide (40?l) or timolol (40?l). These results may suggest the use of this melatonin analogue for the treatment of those ocular conditions, which involve an abnormal raise of intraocular pressure.
Involved external institutions
Spain (ES)How to cite
APA:
Martinez-Aguila, A., Fonseca, B., Bergua, A., & Pintor, J. (2013). Melatonin analogue agomelatine reduces rabbit's intraocular pressure in normotensive and hypertensive conditions. European Journal of Pharmacology, 701(1-3), 213-7. https://doi.org/10.1016/j.ejphar.2012.12.009
MLA:
Martinez-Aguila, Alejandro, et al. "Melatonin analogue agomelatine reduces rabbit's intraocular pressure in normotensive and hypertensive conditions." European Journal of Pharmacology 701.1-3 (2013): 213-7.
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