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Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata.

Bertol JW, Rigotto C, Maia de Pádua R, Kreis W, Barardi CRM, Braga FC, Simões CMO (2011)

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Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2011

Journal

Publisher: Elsevier Masson

Book Volume: 92

Pages Range: 73-90

Journal Issue: 1

DOI: 10.1016/j.antiviral.2011.06.015

Abstract

Cardiac glycosides, known ligands of the sodium pump, are widely used in the treatment of heart failure, such as digoxin and digitoxin. Besides this important activity, other biological activities, such as the antiviral activity, have been described for this group. HSV are responsible for many infections of oral, ocular and genital regions. Treatment with nucleoside analogs such as acyclovir is effective in most cases; however drug-resistance may arise due to prolonged treatment mainly in immunocompromised individuals. In this study, an antiherpes screening was performed with 65 cardenolide derivatives obtained from different sources, and one natural cardenolide, glucoevatromonoside, inhibited HSV-1 and HSV-2 replication at very low concentrations. This cardenolide showed viral inhibitory effects if added up to 12h p.i. and these effects appear to take place by the inhibition of viral proteins synthesis (ICP27, U L42, gB, gD), the blockage of virus release and the reduction of viral cell-to-cell spread. This compound also showed synergistic antiviral effects with acyclovir and anti-Na ⁺K ⁺ATPase activity, suggesting that cellular electrochemical gradient alterations might be involved in the mechanism of viral inhibition. These results suggest that cardenolides might be promising for future antiviral drug design. © 2011 Elsevier B.V.

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How to cite

APA:

Bertol, J.W., Rigotto, C., Maia de Pádua, R., Kreis, W., Barardi, C.R.M., Braga, F.C., & Simões, C.M.O. (2011). Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Research, 92(1), 73-90. https://doi.org/10.1016/j.antiviral.2011.06.015

MLA:

Bertol, Jessica Wildgrube, et al. "Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata." Antiviral Research 92.1 (2011): 73-90.

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