Altered cardiac gene expression of noradrenaline enzymes, transporter and β-adrenoceptors in rat model of rheumatoid arthritis
Dronjak S, Stefanovic B, Jovanovic P, Spasojevic N, Jankovic M, Jeremic I, Hoffmann M (2017)
Publication Type: Journal article
Publication year: 2017
Journal
DOI: 10.1016/j.autneu.2017.10.003
Abstract
Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats. In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline. During the chronic phase, reduced expression of ?1-adrenoceptor and decreased efficiency of noradrenaline reuptake contribute to progressive damage of the myocardium and limits heart efficiency.
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Serbia (RS)How to cite
APA:
Dronjak, S., Stefanovic, B., Jovanovic, P., Spasojevic, N., Jankovic, M., Jeremic, I., & Hoffmann, M. (2017). Altered cardiac gene expression of noradrenaline enzymes, transporter and β-adrenoceptors in rat model of rheumatoid arthritis. Autonomic Neuroscience-Basic & Clinical. https://doi.org/10.1016/j.autneu.2017.10.003
MLA:
Dronjak, Sladjana, et al. "Altered cardiac gene expression of noradrenaline enzymes, transporter and β-adrenoceptors in rat model of rheumatoid arthritis." Autonomic Neuroscience-Basic & Clinical (2017).
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