Prediction of therapy response in acromegalic patients under pegvisomant therapy within the German ACROSTUDY cohort

Sievers C, Baur DM, Schwanke A, Buchfelder M, Droste M, Mann K, Stalla GK (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Pituitary Springer Verlag (Germany)

Book Volume: 18

Pages Range: 916-23

Journal Issue: 6

DOI: 10.1007/s11102-015-0673-2

Abstract

This study aimed at investigating predicting factors for therapy response under growth hormone receptor antagonist therapy with a focus on subjective and patient-oriented measures.Observational, multicenter nested-cohort study including 271 selected patients with the diagnosis of acromegaly and a minimum of one-year follow-up period within the German ACROSTUDY cohort (total cohort: n = 514). Outcome measures were the change of the biomarker IGF-1 (IGF-1 change and IGF-1 normalisation) between baseline and after 1 year of pegvisomant therapy (12 ± 6 months). Main predictors were patient-assessed subjective measures according to the Patient-Assessed Acromegaly Symptom Questionnaire (PASQ) in conjugation with age, gender, BMI, max. dosage of pegvisomant at follow-up and IGF-1 before the start of pegvisomant therapy.The mean age of the study population was 51.2 (13.9) years and the mean BMI was 29.5 (5.1) kg/m(2). In adjusted analyses, none of the individual perceived health (PASQ) scores, but age, BMI and IGF-1 at baseline were predictive for an IGF-1 decrease after 1 year of pegvisomant therapy and BMI and IGF-1, but equally none of the PASQ items, were predicting IGF-1 normalisation.Age, BMI and baseline IGF-1 but not subjective perceived health measures predict therapy response under second line medical therapy with pegvisomant.

Authors with CRIS profile

Michael Buchfelder Lehrstuhl für Neurochirurgie

Involved external institutions

Pfizer Pharma GmbH DE Germany (DE) Max-Planck-Institut für Psychiatrie (Deutsche Forschungsanstalt für Psychiatrie) DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE)

How to cite

APA:

Sievers, C., Baur, D.M., Schwanke, A., Buchfelder, M., Droste, M., Mann, K., & Stalla, G.K. (2015). Prediction of therapy response in acromegalic patients under pegvisomant therapy within the German ACROSTUDY cohort. Pituitary, 18(6), 916-23. https://doi.org/10.1007/s11102-015-0673-2

MLA:

Sievers, Caroline, et al. "Prediction of therapy response in acromegalic patients under pegvisomant therapy within the German ACROSTUDY cohort." Pituitary 18.6 (2015): 916-23.

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