Crosstalk between microbiota, pathogens and the innate immune responses

Günther C, Josenhans C, Wehkamp J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

International Journal of Medical Microbiology Elsevier

Book Volume: 306

Pages Range: 257-65

Journal Issue: 5

DOI: 10.1016/j.ijmm.2016.03.003

Abstract

Research in the last decade has convincingly demonstrated that the microbiota is crucial in order to prime and orchestrate innate and adaptive immune responses of their host and influence barrier function as well as multiple developmental and metabolic parameters of the host. Reciprocally, host reactions and immune responses instruct the composition of the microbiota. This review summarizes recent evidence from experimental and human studies which supports these arms of mutual relationship and crosstalk between host and resident microbiota, with a focus on innate immune responses in the gut, the role of cell death pathways and antimicrobial peptides. We also provide some recent examples on how dysbiosis and pathogens can act in concert to promote intestinal infection, inflammatory pathologies and cancer. The future perspectives of these combined research efforts include the discovery of protective species within the microbiota and specific traits and factors of microbes that weaken or enforce host intestinal homeostasis.

Authors with CRIS profile

Claudia Günther Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Involved external institutions

Eberhard Karls Universität Tübingen DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Günther, C., Josenhans, C., & Wehkamp, J. (2016). Crosstalk between microbiota, pathogens and the innate immune responses. International Journal of Medical Microbiology, 306(5), 257-65. https://doi.org/10.1016/j.ijmm.2016.03.003

MLA:

Günther, Claudia, Christine Josenhans, and Jan Wehkamp. "Crosstalk between microbiota, pathogens and the innate immune responses." International Journal of Medical Microbiology 306.5 (2016): 257-65.

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