MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through ROR?t? T cells

Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Vöhringer D, Hase K, Honda K, Sakaguchi S, Eberl G (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Science American Association for the Advancement of Science

Book Volume: 349

Pages Range: 989-93

Journal Issue: 6251

DOI: 10.1126/science.aac4263

Abstract

Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that microbiota-induced T(regs) express the nuclear hormone receptor ROR?t and differentiate along a pathway that also leads to T(H)17 cells. In the absence of ROR?t(+) T(regs), T(H)2-driven defense against helminths is more efficient, whereas T(H)2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 ROR?t(+) T(regs) and T(H)17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.

Authors with CRIS profile

David Vöhringer Department of Infection Biology

Involved external institutions

Institut Pasteur FR France (FR) Osaka University / 大阪大学 JP Japan (JP) Riken Institute of Physical and Chemical Research / 理化学研究所 JP Japan (JP) University of Tokyo JP Japan (JP) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) FR France (FR) Vienna Biocenter VBC AT Austria (AT) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Ohnmacht, C., Park, J.-H., Cording, S., Wing, J.B., Atarashi, K., Obata, Y.,... Eberl, G. (2015). MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through ROR?t? T cells. Science, 349(6251), 989-93. https://doi.org/10.1126/science.aac4263

MLA:

Ohnmacht, Caspar, et al. "MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through ROR?t? T cells." Science 349.6251 (2015): 989-93.

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