Löber S, Gmeiner P (2007)
Publication Type: Journal article
Publication year: 2007
Publisher: Wiley-VCH Verlag: No OnlineOpen
Book Volume: 26
Pages Range: 1145-1150
The copper catalyzed [3 + 2]-cycloaddition of azides and alkynes has attracted enormous attention due to its striking suitability for the construction of bioconjugates, polymers, and bioactive small molecules. We herein present new, readily approachable polymer-supported scavenger resins allowing an efficient and high yielding parallel synthesis of 1,4-substituted 1,2,3-triazoles. Azidomethyl-substituted polystyrene 1 and the alkynoyl-amino functionalized resin 3 proved to quantitatively remove unreacted alkynes and azides, respectively. Model libraries of triazole derivatives could be obtained in high yield and excellent purity suggesting the application of this practical methodology for parallel solution phase chemistry. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
APA:
Löber, S., & Gmeiner, P. (2007). Optimization of Click Chemistry Using Azide and Alkyne Scavenger Resins. Qsar & Combinatorial Science, 26, 1145-1150. https://doi.org/10.1002/qsar.200740065
MLA:
Löber, Stefan, and Peter Gmeiner. "Optimization of Click Chemistry Using Azide and Alkyne Scavenger Resins." Qsar & Combinatorial Science 26 (2007): 1145-1150.
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