Gmeiner P (2006)
Publication Type: Journal article
Publication year: 2006
Publisher: Elsevier
Book Volume: 62
Pages Range: 8919-8927
DOI: 10.1016/j.tet.2006.07.007
As cis/trans prolyl isomerization plays a crucial role in various biological processes, peptide mimics capable of modifying the cis/trans Xaa-Pro ratio are of particular interest. A practical approach toward proline derived triazolopeptides employing [3+2] azide-alkyne cycloadditions as the key reaction step and the analysis of their cis/trans prolyl ratios are reported. Structural investigations indicated the adjustability of both the cis-percentage and the conformational stability toward intramolecular H-bonding effects. © 2006 Elsevier Ltd. All rights reserved.
APA:
Gmeiner, P. (2006). Triazolopeptides: chirospecific synthesis and cis/trans prolyl ratios of structural isomers. Tetrahedron, 62, 8919-8927. https://doi.org/10.1016/j.tet.2006.07.007
MLA:
Gmeiner, Peter. "Triazolopeptides: chirospecific synthesis and cis/trans prolyl ratios of structural isomers." Tetrahedron 62 (2006): 8919-8927.
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