Click Linker: Efficient and High-Yielding Synthesis of a New Family of SPOS Resins by 1,3-Dipolar Cycloaddition

Löber S, Gmeiner P (2003)

Publication Type: Journal article

Publication year: 2003

Journal

Organic Letters American Chemical Society

Publisher: American Chemical Society

Book Volume: 5

Pages Range: 1753-1755

Journal Issue: 10

DOI: 10.1021/ol034520l

Abstract

(Matrix presented) Highly efficient methodology for the construction of functionalized resins was presented involving 1,3-dipolar cycloaddition as the key reaction step. On the basis of this concept, the first series of click backbone amide linkers were synthesized and the application of the FIMT resin 3f to the parallel synthesis of putative dopaminergic agents was demonstrated leading to the selective receptor ligands 10i and 10s revealing high affinity to the D4 subtype.

Authors with CRIS profile

Stefan Löber Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

How to cite

APA:

Löber, S., & Gmeiner, P. (2003). Click Linker: Efficient and High-Yielding Synthesis of a New Family of SPOS Resins by 1,3-Dipolar Cycloaddition. Organic Letters, 5(10), 1753-1755. https://doi.org/10.1021/ol034520l

MLA:

Löber, Stefan, and Peter Gmeiner. "Click Linker: Efficient and High-Yielding Synthesis of a New Family of SPOS Resins by 1,3-Dipolar Cycloaddition." Organic Letters 5.10 (2003): 1753-1755.

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