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Synthesis of Enantiopure 8-Aminomethylindolizines from Glutamine by Stereoelectronically Controlled Cationic Cyclization

Gmeiner P (2000)

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Publication Type: Journal article

Publication year: 2000

Journal

Publisher: Elsevier

Book Volume: 53

Pages Range: 1371-1378

Journal Issue: 13

Abstract

Starting from natural glutamine the synthesis of the 8- aminomethylindolizine (4b) was accomplished. The construction of the ring system was performed by employing a cationic 6-exo π-cyclization of an intermediate aziridinium salt. Transformation of the N,N-dibenzyl protected amine (4b) into the pharmacologically relevant target compound (11) is also described.

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How to cite

APA:

Gmeiner, P. (2000). Synthesis of Enantiopure 8-Aminomethylindolizines from Glutamine by Stereoelectronically Controlled Cationic Cyclization. Heterocycles, 53(13), 1371-1378.

MLA:

Gmeiner, Peter. "Synthesis of Enantiopure 8-Aminomethylindolizines from Glutamine by Stereoelectronically Controlled Cationic Cyclization." Heterocycles 53.13 (2000): 1371-1378.

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