Enantio- and Diastereocontrolled Dopamine D1, D2, D3 and D4 Receptor Binding of N-(3-Pyrrolidinylmethyl)benzamides Synthesized from Aspartic Acid

Hübner H, Gmeiner P (1999)

Publication Type: Journal article

Publication year: 1999

Journal

Bioorganic & Medicinal Chemistry Letters Elsevier

Publisher: Elsevier

Book Volume: 9

Pages Range: 841-846

DOI: 10.1016/S0960-894X(99)00086-4

Abstract

Subreceptor selectivity tuning of N-(3-pyrrolidinyl)benzamides leading to the selective dopamine D3 ligand ent1h and the derivatives 1g and 1e/ent1e which preferably recognize human D2 or D4 receptors, respectively, is described. Binding profiles were controlled by both, absolute and relative configuration. The enantiopure target compounds were synthesized from aspartic acid.

Authors with CRIS profile

Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie

How to cite

APA:

Hübner, H., & Gmeiner, P. (1999). Enantio- and Diastereocontrolled Dopamine D1, D2, D3 and D4 Receptor Binding of N-(3-Pyrrolidinylmethyl)benzamides Synthesized from Aspartic Acid. Bioorganic & Medicinal Chemistry Letters, 9, 841-846. https://doi.org/10.1016/S0960-894X(99)00086-4

MLA:

Hübner, Harald, and Peter Gmeiner. "Enantio- and Diastereocontrolled Dopamine D1, D2, D3 and D4 Receptor Binding of N-(3-Pyrrolidinylmethyl)benzamides Synthesized from Aspartic Acid." Bioorganic & Medicinal Chemistry Letters 9 (1999): 841-846.

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