Waibel R, Gmeiner P (1999)
Publication Type: Journal article
Publication year: 1999
Publisher: Elsevier
Book Volume: 51
Pages Range: 1389-1400
Starting from natural asparagine the synthesis of the N-protected enantiomerically pure 3- and 4-aminopyrrolidinones (1) and (3) was accomplished. The incorporation of these building blocks into conformationally constrained peptidomimetics was demonstrated by the synthesis of the potential dopamine receptor modulator (14b) (β-PAOPA). Furthermore, Freidinger γ-lactams including the protected dipeptide mimetics (8a-c) and (9) were prepared. The optical integrity of the synthesis was established by NMR analysis of the ureas (10a,b).
APA:
Waibel, R., & Gmeiner, P. (1999). Chemo- and Regioselective Syntheses of Enantiopure Aminopyrrolidinones as Building Blocks for Constrained Peptidomimetics. Heterocycles, 51, 1389-1400.
MLA:
Waibel, Reiner, and Peter Gmeiner. "Chemo- and Regioselective Syntheses of Enantiopure Aminopyrrolidinones as Building Blocks for Constrained Peptidomimetics." Heterocycles 51 (1999): 1389-1400.
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