Homo-Freidinger Lactams: Stereoselective Synthesis of 4-Aminopiperidin-2-one Derivatives from Aspartic Acid

Gmeiner P (1998)


Publication Type: Journal article

Publication year: 1998

Journal

Publisher: Thieme Publishing / Georg Thieme Verlag

Pages Range: 885-887

Abstract

Starting from aspartic acid a stereoselective synthesis of enantiomerically pure 4-aminopiperidin-2-ones which can serve as conformationally restrained β-amino acid equivalents in peptidomimetics is described. The synthesis is based on the regioselective functionalization of the 1,4-bis-electrophile 2b and a diastereoselective introduction of various side chain equivalents into the lactam α-position of 4b,c.

Authors with CRIS profile

How to cite

APA:

Gmeiner, P. (1998). Homo-Freidinger Lactams: Stereoselective Synthesis of 4-Aminopiperidin-2-one Derivatives from Aspartic Acid. Synlett, 885-887.

MLA:

Gmeiner, Peter. "Homo-Freidinger Lactams: Stereoselective Synthesis of 4-Aminopiperidin-2-one Derivatives from Aspartic Acid." Synlett (1998): 885-887.

BibTeX: Download