Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases

Linz S, Müller J, Hübner H, Gmeiner P, Troschütz R (2009)

Publication Type: Journal article, Original article

Publication year: 2009

Journal

Bioorganic & Medicinal Chemistry Elsevier

Original Authors: Linz S., Muller J., Hubner H., Gmeiner P., Troschutz R.

Publisher: Elsevier

Book Volume: 17

Pages Range: 4448-4458

Journal Issue: 13

DOI: 10.1016/j.bmc.2009.05.015

Abstract

A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (K = 1,9 nM) and 34d (K = 2,4 nM) as well as the pyrrolo[3,2-d]pyrimidine Mannich base 49f (K = 2,8 nM) showed high dopamine D4 receptor activity superior to the atypical antipsychotic agent clozapine. © 2009 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Harald Hübner Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Reinhard Troschütz Naturwissenschaftliche Fakultät

How to cite

APA:

Linz, S., Müller, J., Hübner, H., Gmeiner, P., & Troschütz, R. (2009). Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. Bioorganic & Medicinal Chemistry, 17(13), 4448-4458. https://doi.org/10.1016/j.bmc.2009.05.015

MLA:

Linz, Sabine, et al. "Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases." Bioorganic & Medicinal Chemistry 17.13 (2009): 4448-4458.

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