Gerlach RG, Walter S, McClelland M, Schmidt C, Steglich M, Prager R, Bender JK, Fuchs S, Schoerner C, Rabsch W, Lang W, Jantsch J (2017)
Publication Type: Journal article
Publication year: 2017
DOI: 10.1016/j.ijmm.2017.09.001
Infections of very young children or immunocompromised people with Salmonella of higher subspecies are a well-known phenomenon often associated with contact to cold-blooded animals. We describe the molecular characterization of three S. enterica subsp. diarizonae strains, isolated consecutively over a period of several months from a hospital patient suffering from diarrhea and sepsis with fatal outcome. With the initial isolate the first complete genome sequence of a member of subsp. diarizonae is provided and based on this reference we revealed the genomic differences between the three isolates by use of next-generation sequencing and confirmed by phenotypical tests. Genome comparisons revealed mutations within gpt, hfq and purK in the first isolate as a sign of clonal variation rather than host-directed evolution. Furthermore, our work demonstrates that S. enterica subsp. diarizonae possess, besides a conserved set of known Salmonella Pathogenicity Islands, a variable portfolio of additional genomic islands of unknown function.
APA:
Gerlach, R.G., Walter, S., McClelland, M., Schmidt, C., Steglich, M., Prager, R.,... Jantsch, J. (2017). Comparative whole genome analysis of three consecutive Salmonella diarizonae isolates. International Journal of Medical Microbiology. https://doi.org/10.1016/j.ijmm.2017.09.001
MLA:
Gerlach, Roman G., et al. "Comparative whole genome analysis of three consecutive Salmonella diarizonae isolates." International Journal of Medical Microbiology (2017).
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