Effective adhesion strength of specifically bound vesicles
Smith AS, Seifert U (2005)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2005
Journal
Publisher: AMERICAN PHYSICAL SOC
Book Volume: 71
Article Number: 061902
Journal Issue: 6
URI: http://journals.aps.org/pre/pdf/10.1103/PhysRevE.71.061902
DOI: 10.1103/PhysRevE.71.061902
Abstract
A theoretical approach has been undertaken in order to model the thermodynamic equilibrium of a 3D vesicle adhering to a flat substrate. The vesicle is treated in a canonical description with a fixed number of sites. A finite number of these sites are occupied by mobile ligands that are capable of interacting with a discrete number of receptors immobilized on the substrate. Explicit consideration of the bending energy of the vesicle shape has shown that the problem of the vesicle shape can be decoupled from the determination of the optimum allocation of ligands over the vesicle. The allocation of bound and free ligands in the vesicle can be determined as a function of the size of the contact zone, the ligand-receptor binding strength, and the concentration of the system constituents. Several approximate solutions for different regions of system parameters are determined and in particular, the distinction between receptor- and ligand-dominated equilibria is found to be important. The crossover between these two types of solutions is found to occur at a critical size of the contact zone. The presented approach enables the calculation of the effective adhesion strength of the vesicle and thus permits meaningful comparisons with relevant experiments as well as connecting the presented model with the proven success of the continuum approach for modeling the shapes of adhering vesicles. The behavior of the effective adhesion strength is analyzed in detail and several approximate expressions for it are given.
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Germany (DE)How to cite
APA:
Smith, A.-S., & Seifert, U. (2005). Effective adhesion strength of specifically bound vesicles. Physical Review E, 71(6). https://doi.org/10.1103/PhysRevE.71.061902
MLA:
Smith, Ana-Suncana, and Udo Seifert. "Effective adhesion strength of specifically bound vesicles." Physical Review E 71.6 (2005).
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