Hard palate hyperpigmentation - a rare side effect of antimalarials

Manger K, von Streitberg U, Seitz G, Kleyer A, Manger B (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Arthritis and Rheumatology Wiley

DOI: 10.1002/art.40327

Abstract

A 50-year old female Caucasian patient with marked xerostomia, xerophthalmia, relapsing parotid swelling, arthralgias, and fatigue had been treated with chloroquine diphosphate (250 mg/day) for four years, when a painless bluish-grey hyperpigmentation of her hard palate was noticed during one of her rheumatologic follow-up visits (A). To rule out malignancy or infection, a mucosal biopsy was performed and histology showed subepithelial granular pigment depositions among collagen fibres and within macrophages (B). Perl's Prussian blue staining confirmed that these deposits contained hemosiderin (C). This article is protected by copyright. All rights reserved.

Authors with CRIS profile

Karin Manger Medizinische Fakultät Arnd Kleyer Department of Medicine 3 – Rheumatology and Immunology Bernhard Manger Professur für Rheumatologie und Klinische Immunologie

Involved external institutions

Sozialstiftung Bamberg DE Germany (DE)

How to cite

APA:

Manger, K., von Streitberg, U., Seitz, G., Kleyer, A., & Manger, B. (2017). Hard palate hyperpigmentation - a rare side effect of antimalarials. Arthritis and Rheumatology. https://doi.org/10.1002/art.40327

MLA:

Manger, Karin, et al. "Hard palate hyperpigmentation - a rare side effect of antimalarials." Arthritis and Rheumatology (2017).

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