Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis

Simon D, Derer A, Andes FT, Lezuo P, Bozec A, Schett G, Herrmann M, Harre U (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Bone Elsevier

Book Volume: 105

Pages Range: 35-41

DOI: 10.1016/j.bone.2017.08.013

Abstract

Bone tissue undergoes permanent and lifelong remodeling with a concerted action of bone-building osteoblasts and bone-resorbing osteoclasts. A precise cooperation between those two cell types is critical in the complex process of bone renewal. Galectin-3 is a member of the ?-galactoside-binding lectin family playing multiple roles in cell growth, differentiation and aggregation. As it has been described to be expressed in bone, galectin-3 might influence bone homeostasis by regulating the function and/or interplay of osteoblasts and osteoclasts. Here, we investigated the role of galectin-3 in osteoclastogenesis and osteoblast-osteoclast interactions. Bone histomorphometric analysis and ?CT measurements revealed a decreased trabecular bone volume and an increased osteoclast number in 12weeks old male galectin-3 knockout mice compared to wildtype littermates. Galectin-3 deficient bone marrow cells displayed a higher osteoclastogenic capacity in ex vivo differentiation assays, associated with elevated TRAF6 mRNA levels, suggesting an intrinsic inhibition of osteoclastogenesis by galectin-3 interfering with RANKL-mediated signaling. Furthermore, the addition of extracellular galectin-3 to murine or human osteoclastogenesis assays inhibited osteoclast formation and osteoclast numbers were higher in co-culture assays with galectin-3 deficient osteoblasts. In conclusion, our data suggest the secretion of galectin-3 as a novel mechanism for osteoblasts to control osteoclastogenesis and to maintain trabecular bone homeostasis independently of the RANKL/OPG-axis.

Authors with CRIS profile

Dominic Simon Medizinische Fakultät Anja Derer Department of Radiation Oncology Aline Bozec Juniorprofessur für Osteoimmunologie Georg Schett Lehrstuhl für Innere Medizin III Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Ulrike Steffen Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

AO Research Institute CH Switzerland (CH)

How to cite

APA:

Simon, D., Derer, A., Andes, F.T., Lezuo, P., Bozec, A., Schett, G.,... Harre, U. (2017). Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone, 105, 35-41. https://doi.org/10.1016/j.bone.2017.08.013

MLA:

Simon, Dominic, et al. "Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis." Bone 105 (2017): 35-41.

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