B-cell-intrinsic STAT6 signaling controls germinal center formation

Turqueti-Neves A, Otte M, Da Costa OP, Hoepken UE, Lipp M, Buch T, Vöhringer D (2014)

Publication Type: Journal article

Publication year: 2014

Journal

European Journal of Immunology Wiley-VCH Verlag

Publisher: Wiley-VCH Verlag

Book Volume: 44

Pages Range: 2130-8

Journal Issue: 7

DOI: 10.1002/eji.201344203

Abstract

Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL-4 and IL-13 by CD4(+) T cells and several innate cell types. IL-4 and IL-13 promote class switch recombination to IgG1 and IgE while their role for germinal center (GC) formation is poorly understood. We found a dramatic reduction in the numbers of GC B cells when investigating different type 2 immune responses in IL-4/IL-13-deficient mice. IL-4/IL-13 from T cells located outside B-cell follicles was sufficient for GC formation. We further revealed that IL-4/IL-13 acts directly on B cells for the formation of a robust GC response. The frequency of apoptotic GC B cells was not altered in the absence of IL-4/IL-13 and proliferation was even enhanced. However, deficiency of signal transducer and activator of transcription 6 signaling in B cells resulted in failure to downregulate the chemotactic receptor Gpr183 (Ebi2) and downregulation of this receptor has been shown to be essential for proper GC B-cell differentiation. Thus, T-cell-derived extrafollicular IL-4/IL-13 and signal transducer and activator of transcription 6-regulated genes in B cells play a critical role for orchestration of the GC response in type 2 immunity.

Authors with CRIS profile

David Vöhringer Professur für Infektionsabwehr und Toleranz

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch DE Germany (DE)

How to cite

APA:

Turqueti-Neves, A., Otte, M., Da Costa, O.P., Hoepken, U.E., Lipp, M., Buch, T., & Vöhringer, D. (2014). B-cell-intrinsic STAT6 signaling controls germinal center formation. European Journal of Immunology, 44(7), 2130-8. https://doi.org/10.1002/eji.201344203

MLA:

Turqueti-Neves, Adriana, et al. "B-cell-intrinsic STAT6 signaling controls germinal center formation." European Journal of Immunology 44.7 (2014): 2130-8.

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