Monotherapy with intravenous vinflunine in patients with advanced or metastatic urothelial cancer after failure of a platinum-containing regimen: a retrospective analysis of german routine data

Hegele A, Goebell P, Matz U, Neuhaus T (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Urologia Internationalis Karger

Publisher: Karger

Book Volume: 92

Pages Range: 174-9

Journal Issue: 2

DOI: 10.1159/000354751

Abstract

Objective: The objective of this retrospective study was to investigate the efficacy and safety of vinflunine monotherapy and the utility of second-line prognostic factors in patients with advanced or metastatic urothelial cancer relapsing/progressing during or after a prior platinum-containing regimen under daily routine clinical conditions in Germany. Methods: The selection was based on the marketing authorization indication and recommendations as well as on the evaluation of second-line prognostic factors issued from prior pivotal trials. Results: Eight centers across Germany provided a total of 21 patient records. Demographic and clinical characteristics were similar to the data previously reported in pivotal trials. Complete and partial response to vinflunine treatment was observed in 1 (4.8%) and 3 (14.3%) patients, respectively, resulting in an overall response rate of 19.1%. The disease control rate reached 47.7%. The median progression-free survival amounted to 4.4 months (95% CI 2.6-6.6), with a median overall survival of 6.2 months (95% CI 3.9-10.7). The observed toxicity profile was manageable and consistent with prior clinical trials: leukopenia (33.3%), neutropenia (9.5%), anemia (9.5%) and hyperglycemia (4.8%). The reported satisfaction rate with the treatment was 90.5 and 61.9% among patients and physicians, respectively. Conclusions: This retrospective study confirms that the clinical outcomes obtained from routine medical practice in Germany with vinflunine in the treatment of advanced/metastatic urothelial cancer are in line with the data observed in prior clinical trials. © 2013 S. Karger AG, Basel.

Authors with CRIS profile

Peter Goebell Urologische Klinik

Involved external institutions

Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) St. Vincenz Krankenhaus Limburg DE Germany (DE)

How to cite

APA:

Hegele, A., Goebell, P., Matz, U., & Neuhaus, T. (2014). Monotherapy with intravenous vinflunine in patients with advanced or metastatic urothelial cancer after failure of a platinum-containing regimen: a retrospective analysis of german routine data. Urologia Internationalis, 92(2), 174-9. https://doi.org/10.1159/000354751

MLA:

Hegele, Axel, et al. "Monotherapy with intravenous vinflunine in patients with advanced or metastatic urothelial cancer after failure of a platinum-containing regimen: a retrospective analysis of german routine data." Urologia Internationalis 92.2 (2014): 174-9.

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