Induction of colitis in mice (T-cell transfer model)

Weigmann B (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Methods in Molecular Biology Humana Press

Publisher: Humana Press, Inc.

Book Volume: 1193

Pages Range: 143-51

DOI: 10.1007/978-1-4939-1212-4_14

Abstract

Animal model of intestinal inflammation is essential for the understanding of the pathomechanisms of inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Typically, naïve T-cells were transferred into immunocompromised mice and develop gut inflammation because of inappropriate downregulation. Here, we describe the isolation, purification, and transfer of CD4(+)CD25(-) T-cells into recipients to obtain an experimental colitis model for the analysis of pathogenesis.

Authors with CRIS profile

Benno Weigmann Medizinische Fakultät

Related research project(s)

None - None

How to cite

APA:

Weigmann, B. (2014). Induction of colitis in mice (T-cell transfer model). Methods in Molecular Biology, 1193, 143-51. https://doi.org/10.1007/978-1-4939-1212-4_14

MLA:

Weigmann, Benno. "Induction of colitis in mice (T-cell transfer model)." Methods in Molecular Biology 1193 (2014): 143-51.

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