Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI
Crema MD, Hunter DJ, Burstein D, Roemer F, Li L, Eckstein F, Krishnan N, Le-Graverand MPH, Guermazi A (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: BMJ Publishing Group
Book Volume: 73
Pages Range: 1935-41
Journal Issue: 11
DOI: 10.1136/annrheumdis-2012-203083
Abstract
To determine the association between changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index over 2 years as a measure of cartilage proteoglycan concentration, with changes in cartilage thickness in the medial tibiofemoral compartment of knees in middle-aged women.One hundred and forty-eight women (one knee for each subject) aged >=40 years were included. 3.0 T MR images of the knee were acquired at baseline, 1 year and 2 years. Three-dimensional (3D) spoiled gradient recalled echo (SPGR) sequences (for cartilage thickness) and 3D inversion recovery-prepared SPGR sequences after dGEMRIC were acquired. Segmentation was performed in the medial central (weight-bearing) femur and tibia to determine cartilage proteoglycan concentration and thickness. The association of change in the dGEMRIC indices between baseline and 1-year follow-up with (a) concomitant changes in cartilage thickness and (b) change in cartilage thickness between 1 and 2 years was assessed using linear regression.In the whole-sample model, a decrease in dGEMRIC indices over time at the central medial femur significantly predicted an increase in cartilage thickness at both the central medial femur (p=0.008) and the medial tibia (p=0.04).A decrease in dGEMRIC indices was associated with an increase in cartilage thickness in the medial compartment. Our results suggest that an increase in cartilage thickness may also be related to a decrease in proteoglycan concentration, which may represent swelling of cartilage in early stages of degeneration.
Authors with CRIS profile
Involved external institutions
Boston University
United States (USA) (US)
University of Sydney (USYD)
Australia (AU)
Harvard University
United States (USA) (US)
New England Baptist Hospital (NEBH)
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
Pfizer, Inc.
United States (USA) (US)
United States (USA) (US)
University of Sydney (USYD)
Australia (AU)
Harvard University
United States (USA) (US)
New England Baptist Hospital (NEBH)
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
Pfizer, Inc.
United States (USA) (US)
How to cite
APA:
Crema, M.D., Hunter, D.J., Burstein, D., Roemer, F., Li, L., Eckstein, F.,... Guermazi, A. (2014). Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI. Annals of the Rheumatic Diseases, 73(11), 1935-41. https://doi.org/10.1136/annrheumdis-2012-203083
MLA:
Crema, Michel D., et al. "Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI." Annals of the Rheumatic Diseases 73.11 (2014): 1935-41.
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