Maschauer S, Prante O (2014)
Publication Type: Journal article
Publication year: 2014
Publisher: Hindawi Publishing Corporation
Book Volume: 2014
Pages Range: 214748
DOI: 10.1155/2014/214748
At the time when the highly efficient [(18)F]FDG synthesis was discovered by the use of the effective precursor 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl- ? -D-mannopyranose (mannose triflate) for nucleophilic (18)F-substitution, the field of PET in nuclear medicine experienced a long-term boom. Thirty years later, various strategies for chemoselective (18)F-labeling of biomolecules have been developed, trying to keep up with the emerging field of radiopharmaceutical sciences. Among the new radiochemical strategies, chemoselective (18)F-fluoroglycosylation methods aim at the sweetening of pharmaceutical radiochemistry by providing a powerful and highly valuable tool for the design of (18)F-glycoconjugates with suitable in vivo properties for PET imaging studies. This paper provides a short review (reflecting the literature not older than 8 years) on the different (18)F-fluoroglycosylation reactions that have been applied to the development of various (18)F-glycoconjugate tracers, including not only peptides, but also nonpeptidic tracers and high-molecular-weight proteins.
APA:
Maschauer, S., & Prante, O. (2014). Sweetening pharmaceutical radiochemistry by (18)f-fluoroglycosylation: a short review. BioMed Research International, 2014, 214748. https://doi.org/10.1155/2014/214748
MLA:
Maschauer, Simone, and Olaf Prante. "Sweetening pharmaceutical radiochemistry by (18)f-fluoroglycosylation: a short review." BioMed Research International 2014 (2014): 214748.
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