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1-Year outcomes of hypertension management in 13,000 outpatients under practice conditions: Prospective 3A registry

Zeymer U, Dechend R, Riemer T, Kaiser E, Senges J, Pittrow D, Schmieder R (2014)

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Publication Type: Journal article

Publication year: 2014

Journal

Publisher: Elsevier

Book Volume: 176

Pages Range: 589-94

Journal Issue: 3

DOI: 10.1016/j.ijcard.2014.07.089

Abstract

Current data on characteristics and outcomes of patients with high blood pressure (BP) managed under clinical practice conditions are limited.The 3A registry is an open, prospective observational cohort study in German primary care offices, with a 4:1:1 inclusion ratio to either aliskiren (ALIS), an ACE inhibitor/angiotensin receptor blocker (ACEI/ARB), or to an antihypertensive agent not affecting the renin angiotensin system (non-RAS). A nonlinear mixed regression model was used to assess BP changes during follow-up regarding different BP values at inclusion in the various groups. ClinicalTrial.gov identifier is NCT01454583. In the total cohort of 13,433 patients with 1-year follow-up results, the mean age of patients was 64.7years, 54% were men. Mean number of antihypertensive drugs was higher in the ALIS group compared to the other groups (3.0 drugs versus 2.5 in ACEI/ARB versus 1.6 in non-RAS; p<0.0001). Statistical regression analysis revealed baseline BP as the dominant covariate. After adjustment for baseline BP and 12 other confounders, no significant differences in BP reduction between the three groups were observed. The rate of major cardiac events (death, myocardial infarction, and stroke) was 1.3% in the total cohort, and did not differ across groups.ALIS at beginning of the observation was mostly used by the physicians in patients with higher BP at entry and in higher risk populations. By study end, in all groups, stringent BP lowering measures, usually with combination therapy, led to significant improvements; more than half of these at-risk patients reached the BP targets.

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How to cite

APA:

Zeymer, U., Dechend, R., Riemer, T., Kaiser, E., Senges, J., Pittrow, D., & Schmieder, R. (2014). 1-Year outcomes of hypertension management in 13,000 outpatients under practice conditions: Prospective 3A registry. International Journal of Cardiology, 176(3), 589-94. https://doi.org/10.1016/j.ijcard.2014.07.089

MLA:

Zeymer, Uwe, et al. "1-Year outcomes of hypertension management in 13,000 outpatients under practice conditions: Prospective 3A registry." International Journal of Cardiology 176.3 (2014): 589-94.

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